Top 5 Minimally Invasive Spine Surgery Companies in 2025

Minimally Invasive Spine Surgery companies are delivering faster recovery, less tissue disruption, and better outcomes. 

As demand for less invasive procedures grows, this blog highlights the top 5 companies leading the global MIS spine market through innovation and clinical performance.

Table of Contents

➜ Why Minimally Invasive Spine Surgery Is Replacing Open Procedures

➜ Top 5 Minimally Invasive Spine Surgery Companies in 2025

↳ 1. Globus Medical / NuVasive

↳ 2. Medtronic

↳ 3. DePuy Synthes (Johnson & Johnson)

↳ 4. Stryker

↳ 5. SI-BONE

➜ Global Market Outlook for Minimally Invasive Spine Surgery

➜ Get a Complimentary Report Summary

Key Takeaways

• The global minimally invasive spine (MIS) implant market reached nearly $4 billion in 2024, projected to grow to $6 billion by 2031 at a CAGR of 5.9%.
  
• Globus Medical/NuVasive leads the MIS interbody market due to a broad portfolio and innovation like XLIF®, MAS®, and MARS™ systems.
  
• Medtronic remains a major player with its MAST platform, DLIF® technique, and leadership in MIS pedicle screws.
  
• DePuy Synthes dominates the MIS facet fixation space and offers systems like VIPER®, COUGAR®, and PIPELINE®.
  
• Stryker brings innovation in LLIF with its LITe® and ZUFUSE® systems, while SI-BONE leads the SI joint fusion segment with iFuse®.
• MIS techniques are gaining traction due to shorter recovery, lower complications, and strong patient/surgeon preference.

 

Why Minimally Invasive Spine Surgery Is Replacing Open Procedures

Minimally invasive spine surgery is becoming the standard of care for various spinal conditions. Unlike traditional open surgeries, minimally invasive spine procedures use smaller incisions and specialized tools, resulting in:

• Less muscle and tissue damage
  
• Shorter hospital stays and faster recovery
  
• Reduced blood loss and infection risk
  
• Lower long-term healthcare costs

 

The preference for these outcomes, both from patients and surgeons, is a key driver of global market growth. As a result, the demand for innovative technologies from leading minimally invasive spine surgery companies continues to climb.

 

Top 5 Minimally Invasive Spine Surgery Companies in 2025

1. Globus Medical / NuVasive

In 2024, Globus Medical and NuVasive together formed the leading competitor in the global minimally invasive spine (MIS) interbody device market.

Following their 2023 merger, they became the most dominant force in both traditional and MIS spinal surgery. 

Their complementary product portfolios, including the XLIF® platform, MAS® procedures, and MARS™ access tools, offer a complete MIS ecosystem across lumbar, cervical, and sacral indications.

NuVasive Highlights:

• XLIF® (eXtreme Lateral Interbody Fusion): Lateral approach enables full disc removal in under an hour.
• MAS® Platform: Includes MAS PLIF and TLIF for lower disruption procedures.
• Modulus®, TLX 20º™, and Cohere® XLIF®: Advanced interbody implants, including porous titanium and PEEK options.
• NVM5® Intraoperative Monitoring System: Real-time physiological data for patient safety.

Globus Medical Highlights:

• MARS™ 3V and MARS™ Port Access: Minimal access retractors for better visualization and precision.
• INDEPENDENCE MIS™, CALIBER®-L, and FORGE® Spacer: Leading products in LLIF and OLIF.
• COALITION MIS™ and CREO MIS™: Expansive cervical and posterior stabilization options.
• LATIS®, RISE®, and SIGNATURE®: Integrated TLIF platforms and expandable cages.

 

Together, they offer unmatched breadth and depth in the minimally invasive spine segment.

 

2. Medtronic

Medtronic ranked second in the global MIS implant market in 2024.

The company led the MIS pedicle screw market and held the #2 position in MIS interbody devices, largely due to its DLIF® procedure and MAST™ technologies. 

Medtronic’s longstanding presence in traditional spine surgery strengthens its minimally invasive offerings, supported by systems like METRx™, Sextant™, and Longitude®.

MIS Portfolio:

• DLIF® (Direct Lateral Interbody Fusion): Anterior-lateral access procedure for lumbar spine fusion.
• MAST™ (Minimal Access Spine Technologies): Includes METRx™, CD Horizon® Sextant™, and Longitude® systems.
• ANCHOR FS™ and SPIRE™: Solutions for facet and spinous process fixation.

 

Medtronic’s CD Horizon® Legacy™ and PEEK rod systems remain widely used, and its strong foothold in traditional spine surgery helps expand its minimally invasive offerings.

 

3. DePuy Synthes (Johnson & Johnson)

DePuy Synthes was the third-leading competitor in the 2024 MIS spine implant market.

The company held strong positions in both MIS pedicle screw and interbody markets and was the global leader in facet fixation, thanks to systems like FACET WEDGE® and VIPER® F2. 

Its PIPELINE®, COUGAR®, and CONCORDE® systems continue to perform across MIS indications.is third in global market share, known for its leadership in facet fixation and innovation in MIS lateral approaches.

Notable Systems:

• FACET WEDGE® & VIPER® F2: Market-leading facet fixation with minimal nerve disruption.
• VIPER® 3D Correction Set: Supports complex deformities like scoliosis.
• PIPELINE® LS and COUGAR® LS: Lateral access and cage systems.
• CONCORDE® and MATRIX® MIS: Broad interbody options and deformity tools.

 

Its Insight Access™ system also enhances MIS decompression and fusion access.

 

4. Stryker

Stryker secured fourth place in the global MIS implant market in 2024.

The company’s market share came from strong sales in MIS interbody and pedicle screw systems, along with a modest presence in spinous process fixation. 

Products like LITe® for LLIF, Xia® screws, and the UniVise™ system reinforce its value in both fusion and stabilization procedures.holds the fourth position, offering intuitive systems for LLIF and posterior stabilization.

Key Products:

• LITe® LLIF Platform: Reduces muscle trauma and incision size.
• Xia® and MANTIS®: Percutaneous pedicle screw systems.
• UniVise™: Unique spinous process fixation with midline locking.
• ZUFUSE®: Facet fixation for degenerative pathologies.
• Techtonix® Band and Luxor® Retractor: Designed for tissue-sparing spinal exposure.

 

Stryker’s strategy integrates MIS implants with proprietary biologics to enhance fusion outcomes.

 

5. SI-BONE

SI-BONE maintained a leading position in the MIS sacroiliac (SI) joint fusion market.

Although more niche than the others, SI-BONE’s dominance in this growing segment, supported by the iFuse® and iFuse-3D™ systems, secured its place in the top 5. 

With more than 50 peer-reviewed studies and FDA-cleared implants, the company continues to set the clinical benchmark for minimally invasive SI joint procedures.

Innovations:

• iFuse Implant System®: Minimally invasive fusion device approved since 2008.
• iFuse-3D™: 3D-printed titanium device promoting ongrowth/ingrowth.
• Eliminates need for BMPs, rods, and threaded cages.
• Supported by 50+ peer-reviewed studies, including success in smokers and opioid users.

SI-BONE’s niche focus and consistent clinical outcomes give it a leadership position in the SI joint segment of the MIS spine market.

 

Global Market Outlook for Minimally Invasive Spine Surgery

The global MIS spine implant market was valued at nearly $4 billion in 2024 and is projected to reach nearly $6 billion by 2031.

The demand for MIS spine procedures is driven by:

• Surgeon preference for less invasive techniques
• Patient demand for reduced recovery times
• Technological advances in expandable cages, navigation, and real-time monitoring
• Health systems’ interest in reducing surgical complications and hospital stays

As innovation accelerates, the leading minimally invasive spine surgery companies are expanding both product portfolios and clinical validation.

 

Get a Complimentary Report Summary

To gain deeper insights into these trends, consider exploring our comprehensive Global Minimally Invasive Spine Surgery Market Report, which provides detailed analysis of the U.S. MIS spinal implant & device market, including:

• Interbody Devices – Supports fusion
• Pedicle Screws – Stabilizes spine
• Spinous Process Fixation – Aligns vertebrae
• Facet Fixation – Enhances stability
• SI Joint Fusion – Strengthens SI joint
• Spine Endoscopes – Aids MIS procedures
• Surgical Tools – Specialized instrumentation

 

Or request a complimentary Global Minimally Invasive Spine Surgery Market Report—completely free.

FREE Sample Report