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NuVasive was formed in 1999 and is currently active in a number of medical device markets including traditional and minimally invasive spinal implants (MIS) as well as dental and orthopedic biomaterials.

 

Top 5 NuVasive Competitors in the U.S. MIS Spine market

  • Medtronic
  • DePuy Synthes
  • Globus Medical
  • Zimmer Biomet
  • Stryker

While NuVasive continues to expand its presence in various areas of the spinal market, their main focus is in developing minimally invasive spinal implants.  The XLIF® procedure is one of the company’s best-known products. The procedure involves a lateral approach to the patient, rather than an anterior or posterior approach. XLIF® provides direct access to the disc space, allowing for complete disc removal and implant insertion.

Another popular lateral lumbar interbody fusion system is Medtronic’s DLIF®. Medtronic closely follows NuVasive as the second-leading competitor in the total MIS market in the United States. Medtronic’s strong presence in the traditional spine market will continue to augment its share in the MIS market space.

DePuy Synthes’ MIS product portfolio contains a number of devices that are widely used in the spinal implant industry. The company holds strong positions in the MIS interbody device and the MIS pedicle screw segments. The main driving force behind DePuy Synthes’ success in the MIS market is the popular VIPER® pedicle screw system. The VIPER® 3D MIS correction set was released in September 2011 and served to expand the indications of the VIPER®2 system to treat complex pathologies such as adult degenerative scoliosis (ADS) and adolescent idiopathic scoliosis (AIS). The newest addition to the VIPER® portfolio is the VIPER PRIME™ system, which was released in 2017 and combines all the pedicle preparation instruments into one comprehensive tool.

Globus Medical participates and shows a moderate performance in each of the MIS interbody fusion, pedicle screw, facet fixation and sacroiliac joint fusion segments. This aggregate effect leads to their strong presence in the total MIS implant market.

Zimmer Biomet attributes their success in the total MIS market to their lead in the facet fixation segment. Zimmer Biomet’s posterior spinous process fixation system, Aspen™ (formerly belonging to Lanx), has been very successful and has gained considerable share since its introduction.

Stryker manufactures a number of MIS products, including the Xia® cannulated polyaxial screw system, the MANTIS® percutaneous pedicle screw system, the Techtonix® posterior tension band and the Luxor® retractor system. Their LLIF product is marketed under the name LITe® and offers less muscle damage than a posterior procedure, as well as, more efficient exposure and closure time due to its smaller necessary incision.

Top 5 NuVasive Competitors in the U.S. Traditional Spine Market

  • Medtronic
  • DePuy Synthes
  • Stryker
  • Zimmer Biomet
  • Globus Medical

NuVasive produces several interbody devices for conventional spinal fusion, such as the CoRoent® Large family and the cervical-focused CoRoent® Small Interbody™ System. In 2017, the company announced expanded indications for its TLX™ Interbody System, used for conventional TLIF procedures. The company has also expanded its fixation portfolio over a number of years to accommodate both open and minimally invasive approaches, as well as hybrid procedures.

The total U.S. traditional spine market is dominated by Medtronic. With only the cervical fixation and interbody device markets as exceptions, the company led almost every segment of the spinal implant market in which it actively competed. Medtronic gained the lead in both the VCF and motion preservation markets upon their acquisition of Kyphon in 2007. However, the lead in the motion preservation market has since been lost to DePuy Synthes due to the success of their two artificial discs.

DePuy Synthes was the only company with both a cervical artificial disc (CAD) and a lumbar artificial disc (LAD) on the U.S. market: the ProDisc®-L and the ProDisc®-C.  However, on December 22, 2017, Centinel Spine completed the acquisition of the prodisc® Total Disc Replacement product line from DePuy Synthes. As a result, DePuy Synthes will effectively lose all of their market share in the motion preservation device market, unless they develop a new line of artificial disc devices. Despite this divesture, DePuy Synthes’ extensive product portfolio contains many devices that are widely used in the industry, effectively contributing to their success in maintaining a notable position in the market.

Stryker offers a competitive line of thoracolumbar fixation and interbody devices. Stryker also has motion preservation devices in development or undergoing clinical trials. Although the clinical trials have not shown consistently positive results, their strong product portfolio and popularity among surgeons allows Stryker to remain a significant player in the spine market. On August 30, 2018, Stryker announced the definite agreement to acquire K2M, effectively expanding its presence in both the traditional and minimally invasive spinal implant markets.

Zimmer previously held a strong position in the U.S. spinal implant market and increased its market share after merging with Biomet in 2015 to form Zimmer Biomet Holdings. The company also gained an extensive line of MIS fusion products when it acquired Endius in 2007.

Globus Medical offers the TransContinental™ PEEK spacer system and a set of extensive instrumentation for minimally invasive LLIF procedures.

Top 5 NuVasive Competitors in the U.S. Orthopedic Biomaterials Market

  • Orthofix
  • Zimmer Biomet
  • Medtronic
  • DePuy Synthes
  • Stryker

NuVasive has a significant, but relatively smaller share in the orthopedic biomaterials market compared to its positions in the traditional and MIS spinal markets. The company is a major player in both the cellular allograft and spinal machined bone allograft markets. NuVasive’s spinal machined bone allograft offerings complement their extensive spinal device product portfolio, including both PEEK and metal.

Orthofix and Zimmer Biomet compete with NuVasive in the cellular allograft market as the three companies collectively hold over three quarters of the total market share for cellular allografts.

Medtronic dominates the U.S. orthopedic biomaterials market due to leading shares in the bone graft substitute, growth factor and spinal machined bone allograft segments.

DePuy Synthes competes with ample success in the bone graft substitute and spinal machined bone allograft markets. The company’s lead in the spinal machined bone allograft market includes ALIF and PLIF implants.

Stryker provides PEEK, metal and machined bone allograft spine fusion interbody devices. Their machined bone allograft line includes cervical, transforaminal and posterior interbody devices.

NuVasive Competitors in the U.S. Dental Bone Grafts Substitutes Market

  • Straumann
  • Osteohealth
  • BioHorizons

NuVasive’s bone graft product Osteocel®, previously used solely in the orthopedics industry and sold by NuVasive themselves, is distributed by ACE Surgical in the dental field through an exclusive distribution agreement.  The product is available in two vial sizes of 1 cc and 5 cc; however, its average selling price lies above both Straumann and Osteohealth’s growth factor products, largely limiting its success in the market.

Since its introduction, Straumann’s Emdogain® has become widely accepted globally for use in periodontal procedures. Straumann’s large dental sales force and relationships with dental specialists have helped to increase the acceptance of Emdogain®.

Osteohealth maintains an exclusive deal with BioMimetic Therapeutics to manufacture GEM 21S®, a product that is almost always sold on a discounted basis, especially when purchased in bulk.

BioHorizons is the leader of the total dental growth factor market and is responsible for distributing the popular and controversial INFUSE® growth factor manufactured by Medtronic. Due to Medtronic’s success in the growth factor market in the orthopedic realm, the company has been able to capitalize and extend its influence in the dental market.

For Further Information

For a deeper analysis of the MIS market, the provides a comprehensive report on units sold, market values, average selling prices, procedure volumes, forecasts, as well as detailed competitive market shares and analysis of all major competitors.

Reports include research for devices related to MIS interbody devices, MIS pedicle screws, spinous process fixation, facet fixation, MIS sacroiliac joint fusion, spine endoscope, and MIS spine instrumentation.