TissuGlu is a urethane-based adhesive that a surgeon can use to connect tissue flaps made during surgery to remove excess fat and skin or to restore weakened or separated abdominal muscles (abdominoplasty surgery). Connecting the tissue flaps with an internal adhesive may reduce or eliminate the need for postoperative surgical draining of fluid between the abdominoplasty tissue flaps.
The liquid is applied drop-wise to the tissue surfaces to be adhered, and then the tissue surfaces are approximated for several minutes to allow the moisture in the tissue to initiate the curing process.The cured product acts as a bonding agent between the tissue layers, to eliminate dead space in the wound.
Cohera’s TissuGlu received CE Market approval in 2011. Since then Cohera has been working on establishing wide acceptance of TissuGlu.
The FDA’s review of TissuGlu included data from a clinical study of 130 participants undergoing elective abdominoplasty surgery. Half of the participants received surgical drains while the other half received TissuGlu and no drains. The study results showed that 73 percent of participants who received TissuGlu required no postoperative interventions to drain fluid that had accumulated between the abdominoplasty tissue flaps.
In the 27% of patients who did require invasive treatments, 21% received needle aspirations alone. Six percent of the TissuGlu group received both needle aspirations and drains for persistent seroma formation.